NSAIDs, a derivative of phenylpropionic acid, ibuprofen has anti-inflammatory, analgesic and antipyretic effect. There is an additional general information about this medication active ingredient ibuprofen: Indications, usages and classification codes: General Information Motrax forms, composition and dosages: Other Nonsteroidal Antiimflammatory Agents.Using during pregnancy and breastfeeding.Indications, usages and classification codes:.In addition to other mechanisms, DHA supplementation may improve cardiovascular health by attenuating the inflammatory response. Mean size of VLDL particles was positively associated with plasma concentrations of neutrophils and CRP. RBC concentrations of SFA and (n-6) PUFA were positively connected and those of 18:1 (n-9) and (n-3) PUFA were negatively associated with plasma concentrations of several inflammatory markers. Within 45 d of supplementation, DHA did not alter the circulating concentration of a number of other inflammatory markers, but within 91 d, it significantly (P<0.05) reduced the concentrations of CRP (15%), IL-6 (23%), granulocyte monocyte-colony stimulating factor (21%) and increased that of anti-inflammatory matrix metalloproteinase-2 (7%). DHA supplementation for 45 and 91 d decreased the number of circulating neutrophils by 11.7 and 10.5 % respectively (P<0.05). Fasting blood samples were collected on -7, 0, 45, 84, and 91d. They received no supplements for the first 8 days then received either 7.5 g/d DHA oil (3 g DHA/d) or olive oil (placebo) for the last 90 d. Hypertriglyceridemic men (n=17/group) aged 39-66 y, participated in a double-blind, randomized, placebo controlled, parallel study.
We determined its effects on circulating concentrations of inflammatory markers and their associations with RBC fatty acids and plasma lipids and lipoproteins.
N-3 polyunsaturated fatty acids (PUFA) reduce inflammation but the anti-inflammatory effect of docosahexenoic acid (DHA) in hypertriglyceridemic men has not been reported. Technical Abstract: Inflammation is an independent risk factor for the development of cardiovascular disease (CVD). Increased intake of DHA may be used in the prevention and management of CVD and stroke. Our results suggest that DHA supplementation may improve cardiovascular health by attenuating the inflammatory response, in addition to the many other benefits (decreased triglycerides, and number of total and small dense LDL particles, remnant like cholesterol particles and increased HDL) we previously reported from this study. Within 45 d of supplementation, DHA did not alter the circulating concentration of a number of other inflammatory markers, but within 90 d, it significantly reduced the concentrations of CRP (15%), Interleukin-6 (23%), and granulocyte monocyte-colony stimulating factor (21%) and increased that of anti-inflammatory matrix metalloproteinase-2 (7%). DHA supplementation for 45 and 90 d decreased the number of circulating neutrophils by 11.7 and 10.5 % respectively. Men with elevated triglycerides (17/group) supplemented their diets with either DHA oil (DHA 3 g/d) or olive oil for 90 days 12-h fasting blood samples were drawn at the start, middle and end of the intervention. We studied the effects of DHA supplementation on the circulating concentration of inflammatory markers including CRP. Fish oils that contain two fatty acids (eicosapentaenoic acid or EPA, and docosahexaenoic acid or DHA) have been reported to reduce the circulating concentration of inflammatory markers, however, the individual effects of these two fatty acids are not known. Serum CRP is now accepted as an independent risk factor of a first myocardial infarction, ischemic stroke, peripheral vascular disease, and all-cause mortality. Circulating concentrations of number of inflammatory markers are used to evaluate the inflammatory status, but the most extensively studied biomarker of inflammation in CVD is C-reactive protein (CRP). Increased inflammation is an important factor causing the development and progression of both these chronic diseases. Interpretive Summary: Cardiovascular disease (CVD) and stroke are the leading cause of all deaths in United States, accounting for 38% of all deaths. Docosahexaenoic Acid Supplementation Decreases Serum C - Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men1-3. Citation: Kelley, D.S., Siegel, D., Fedor, D.M., Adkins, Y.C., Mackey, B.E.
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